Relationship of MTB Positive Cases with CD4+ Count and Qualitative Leucocytes and Values of Erythrocyte Sedimentation Rate in MTB Positive Cases in Gombe State
Doughari James Hamuel,
Ja’afaru Mohammed Inuwa,
Luka Joseph
Issue:
Volume 7, Issue 3, May 2022
Pages:
37-42
Received:
1 May 2022
Accepted:
24 May 2022
Published:
28 July 2022
DOI:
10.11648/j.ajlm.20220703.11
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Abstract: Tuberculosis caused by Mycobacterium tuberculosis (M. tuberculosis) bacteria [link.springer.com] remains deadliest communicable disease. In this study the relationship of MTB positive cases with CD4+ count quantitative and qualitative leucocytes and values of erythrocyte sedimentation rate (ESR) in MTB positive cases of patients with suspected pulmonary tuberculosis in Gombe State, Nigeria was determined. Four hundred (400) sputum and blood samples were collected from tuberculosis suspects referred to the laboratory from TB clinics in three Senatorial Zones of Gombe State. The sputum samples were analyzed using GeneXpert MTB/RIF and culture on MGIT tubes and LJ slants methods. The CD4+count determination was carried out using BD FACSCOUNT flow cytometery automated machine (BD Biosciences, 2007 Germany). Complete blood count determination was carried out using 5 - Part SYSMEX XN-330 HAEMATOLOGY ANALYZER (SYSMEX CORPORATION 2017). Result from this study showed Males have higher percentage MTB positivity cases than the females. However, both males and female within the age groups 25 to 54 years showed high rate of MTB positive cases. Mean CD4+ count of MTB positive patients obtained in this study was significantly lower (337.0 ±1.4) than that of the apparently healthy control (753.6 ±1.28). In this study the mean Haemoglobin (Hb) values (9.8 ±3.12 g/dL) among TB patients were lower than those the control group (13.7±2.71 g/dL) for both males and females. Result from this study also showed that the mean neutrophil count value (55.1 ±13.8) of infected patients was higher than that of the healthy control group (46.3 ±22.19) and the mean lymphocytes count value (34.7 ±13.5) of infected patients was lower compared to healthy control group value (42.13 ±20.59). Report from this study showed high proportion of MTB positive patients in Gombe State have subnormal CD4+ count cells, lymphocytopenia, anaemia, neutropenia, thrombocytosis, leucocytosis and high erythrocyte sedimentation rate level before starting treatment.
Abstract: Tuberculosis caused by Mycobacterium tuberculosis (M. tuberculosis) bacteria [link.springer.com] remains deadliest communicable disease. In this study the relationship of MTB positive cases with CD4+ count quantitative and qualitative leucocytes and values of erythrocyte sedimentation rate (ESR) in MTB positive cases of patients with suspected pulm...
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Histopathologic Patterns of Lymph Node Diseases Among Patients Diagnosed in Hawassa University Comprehensive Specialized Hospital, Southern Ethiopia
Tesfalem Israel Korga,
Abebe Melis Nisiro,
Berhanu Lijalem Yigez,
Selamawit Abebe Ayele,
Deginesh Dawit Woltamo,
Yohannes Zewde,
Abebe Sorsa Badacho
Issue:
Volume 7, Issue 3, May 2022
Pages:
43-48
Received:
20 June 2022
Accepted:
1 August 2022
Published:
9 August 2022
DOI:
10.11648/j.ajlm.20220703.12
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Views:
Abstract: Lymphadenopathy is one of the most typical clinical presentations in patients of all age groups. The causes are different based on age, sex, duration, and patterns of involvement. There is a lack of evidence on histopathologic patterns of lymph node diseases. This study aims to determine the histopathologic pattern of lymph node diseases diagnosed in Hawassa university's comprehensive specialized hospital. An institution-based cross-sectional study was conducted among 188 histopathologically diagnosed lymph node biopsies received from September 2014 to August 2020 at Hawassa university's comprehensive specialized hospital (HUCSH). All the samples collected for the diagnoses at a given period were included in the study. The collected data was cleaned and entered into open Epi- version 3 and exported to SPSS version 20 statistical software for analysis. Descriptive analyses like frequency distribution, proportion and dispersion were calculated. The finding was presented using frequency tables, graphs, and charts. Both univariate and multivariate analyses were done. The Adjusted Odd Ratio (AOR with 95% CI) was used to show the strength of the association, and a P-value of ≤ 0.05 was considered statistically significant. Of the 188 lymph node biopsies, 119 (63.3%) were male cases, and 69 (36.7%) were female cases. The age range of the study subjects is 1 to 84 years, with a mean of 31.28±18. 64 years. Localized lymphadenopathy (LAP) was found in 168 (89.4%) of the patients, and the remaining 20 (10.6%) were generalized. Among localized LN groups, cervical, mesenteric, and inguinal LN groups are the most commonly biopsied groups accounting for 66 (35.1%), 55 (29.3%) and 14 (7.4%), respectively. Regarding the size, 72.2% of benign reactive conditions were less than 2cm, whereas 74.5% of lymphomas have a size of at least 2cm. 86.9% of nonspecific reactive conditions have a duration of less than one month, whereas 89% of malignant conditions collectively presented with LAP of more than 1-month duration. A third of 61 (32.4%) were identified as histopathologically reactive nonspecific conditions and lymphomas consist 44 (23.4%) and metastatic lesions (40, 21.3%) and tuberculosis lymphadenitis (36, 19.1%). This study's histopathologic pattern of Lymph Node (LN) disease was comparable with other developing countries. Reactive nonspecific conditions and tuberculous lymphadenitis are more common before the age of 45 years. Metastatic lesions were found more common after the age of 45 years.
Abstract: Lymphadenopathy is one of the most typical clinical presentations in patients of all age groups. The causes are different based on age, sex, duration, and patterns of involvement. There is a lack of evidence on histopathologic patterns of lymph node diseases. This study aims to determine the histopathologic pattern of lymph node diseases diagnosed ...
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