11-year Surveillance of the Epidemiological and Bacteriological Profile of Osteoarticular Infections in Children

Hajar Skali; Fatima Zahrae Lazrak; Asmae Lamrani Hanchi; Tarik Salama; El Mohtadi Aghoutane; Redouane El Fezzazi; Nabila Soraa

doi:doi:10.11648/j.ajlm.20220702.11

11-year Surveillance of the Epidemiological and Bacteriological Profile of Osteoarticular Infections in Children

Hajar Skali, Fatima Zahrae Lazrak, Asmae Lamrani Hanchi, Tarik Salama, El Mohtadi Aghoutane, Redouane El Fezzazi, Nabila Soraa

Published in American Journal of Laboratory Medicine (Volume 7, Issue 2)

Received: 17 February 2022 Accepted: 4 March 2022 Published: 12 March 2022

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Abstract

Osteoarticular infections are an important cause of morbidity and mortality in the pediatric age group. Staphylococcus aureus is the most frequently identified. Early adequate and multidisciplinary care is required. Recently, an increasing incidence of OAI has been related to the improvement of identification methods of microorganism. The aim of this study was to describe, over a period of 11 years, the epidemiological and bacteriological profile of pediatric osteoarticular infections. This retrospective study conducted at the Microbiology Department of the University Hospital of Marrakech over a period of 11 years (2010-2020) including all strains isolated from synovial fluid or bone or joint samples obtained from the pediatric orthopedic surgery department. Six hundred thirty-nine samples were analyzed. The positivity rate to bacteria was at 56,5%. The mean age was 6,5 years. The male gender was predominant with a sex-ratio at 2,65. Arthritis represented 60%. The main etiological agent was Staphylococcus aureus, followed by Streptococcus Beta hemolytic group A (13,3%). Strains of Enterobacteriaceae (EB) were resistant to third-generation cephalosporins by production of Extended Spectrum Betalactamase in 45% of cases. An early diagnosis and start of antimicrobial treatment are crucial for good patient outcome, as well as the control of the infectious focus. Cytobacteriological examination is essential in order to isolate the germ, to study its susceptibility to antibiotics.

Published in	American Journal of Laboratory Medicine (Volume 7, Issue 2)
DOI	10.11648/j.ajlm.20220702.11
Page(s)	23-27
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Arthritis, Pediatric, Bacterial Arthritis, Osteoarticular Infection, Staphylococcus aureus

References

[1]	Mitha A, Boulyana M, Hue V, Pruvost I, Martinot A, European French-speaking expert group. Dubos F. Consensus in diagnostic definitions for bone or joint infections in children by a Delphi method with European French-speaking experts. Acta Paediatr. 2012; 101 (8): e350–e356. [PubMed] [Google Scholar].
[2]	Copley LA. Pediatric musculoskeletal infection: trends and antibiotic recommendations. J Am Acad Orthop Surg. 2009 Oct; 17 (10): 618-26. doi: 10.5435/00124635-200910000-00004. PMID: 19794219.
[3]	Murillo O, Grau I, Lora-Tamayo J, Gomez-Junyent J, Ribera A, Tubau F, Ariza J, Pallares R. The changing epidemiology of bacteraemic osteoarticular infections in the early 21st century. Clin Microbiol Infect. 2015 Mar; 21 (3): 254. e1-8. doi: 10.1016/j.cmi.2014.09.007. Epub 2014 Oct 12. PMID: 25618436.
[4]	Trifa M, Bouchoucha S, Smaoui H, Frikha M, Ben Marzouk S, Ben Ghachem M, Kechrid A, Fekih Hassen A, Ben Khalifa S. Microbiological profile of haematogenous osteoarticular infections in children. Orthop Traumatol Surg Res. 2011 Apr; 97 (2): 186-90. doi: 10.1016/j.otsr.2010.10.005. Epub 2011 Mar 2. PMID: 21371961.
[5]	Ferroni A, Al Khoury H, Dana C et al. Prospective survey of acute osteoarticular infections in a French paediatric orthope- dic surgery unit. Clin Microbiol Infect. 2013; 19: 822-8.
[6]	Ceroni D, Kampouroglou G, Anderson della Llana R et al. Osteoarticular infections in young children: what has changed over the last years? Swiss Med Wkly, 2014; 144: 1-13.
[7]	Lazzarini L, Lipsky BA, Mader JT. Antibiotic treatment of osteomyelitis: what have we learned from 30 years of clinical trials? Int J Infect Dis. 2005; 9: 127-38.
[8]	Gutierrez K. Bone and joint infections in children. Pediatr Clin North Am. 2005 Jun; 52 (3): 779-94, vi. doi: 10.1016/j.pcl.2005.02.005. PMID: 15925662.
[9]	Ohl CA, Berbari EF, Steckelberg JM, Osmon DR. Bone and joint infections. In: Mandell GL, Bennett JE, Dolin R, editors. Mandell, Douglas and Benett’s Principales and practice of infection diseases, 6th ed. Philadelphia, Pa: Churchill Living- stone Elsevier, 2004. 1311-32.
[10]	Krogstad P. Osteomyelitis and septic arthritis. In: Feigin RD, Cherry JD, Demmler GJ et al., editors. Textbook of pediatric infectious diseases. 5th ed. Philadelphia: WB Saunders, 2004. 713-36.
[11]	Moumile K, Merckx J, Glorion C, Pouliquen JC, Berche P, Ferroni A. Bacterial aetiology of acute osteoarticular infections in children. Acta Paediatr 2005; 94: 419-22.
[12]	Bonhoeffer J, Haeberle B, Schaad UB, Heininger U. Diagnosis of acute haematogenous osteomyelitis and septic arthritis: 20 years experience at the University Children’s Hospital Basel. Swiss Med Wkly 2001; 131: 575-81.
[13]	Jaña FC NETO, Ortega CS, Goiano EO. EPIDEMIOLOGICAL STUDY OF OSTEOARTICULAR INFECTIONS IN CHILDREN. Acta Ortop Bras. 2018 May-Jun; 26 (3): 201-205. doi: 10.1590/1413-785220182603145650. PMID: 30038548; PMCID: PMC6053965.
[14]	Wang CL, Wang SM, Yang YJ, Tsai CH, Liu CC. Septic arthritis in children: relationship of causative pathogens, complications, and outcome. J Microbiol Immunol Infect 2003; 36: 41-6.
[15]	Timsit S, Pannier S, Glorion C, Chéron G. Infections bactériennes ostéoarticulaires du nourrisson et de l’enfant: expérience sur un an. Arch Pediatr 2005; 12: 16-22.
[16]	Mahmoud M, Oumokhtar B, Moutaouakil K et al. Epidémiologie nationale des infections ostéo-articulaires chez l’enfant. 6ème Congrés National SOMIPEV Marrakech, du 6, 7 et 8 Avril 2018.
[17]	Saavedra-Lozano J, Falup-Pecurariu O, Faust SN, Girschick H, Hartwig N, Kaplan S, et al. Bone and joint infections. PediatrInfect Dis J. 2017; 36: 788-99.
[18]	Iliadis AD, Ramachandran M. Paediatric bone and joint infec-tion. EFORT Open Rev. 2017; 2: 7-12.
[19]	Ryan MJ, Kavanagh R, Wall PG, Hazleman BL. Bacterial joint infections in England and Wales: analysis of bacterial isolates over a four-year period. Br J Rheumatol 1997; 36: 370-3.
[20]	Weston VC, Jones AC, Bradbury N, Fawthrop F, Doherty M. Clinical features and outcome of septic arthritis in a single UK Health District 1982—1991. Ann Rheum Dis 1999; 58: 214-9.
[21]	Cherkaoui A et al. diagnosis of Kingella kingae osteoarticular infections by specific real-time PCR Assay. J Med Microbiol 2009; 58: 65.
[22]	Ilharreborde B et al. New real-time PCR-based method for Kingella kingae DNA detection: application to samples collected from 89 children with acute arthritis. J Clin Microbiol 2009; 47: 1837-41.
[23]	Sieniawski K et al. Acinetobacter baumannii nosocomial infections. Pol Przegl Chir. 2013 Sep; 85 (9): 483-90. doi: 10.2478/pjs-2013-0075. PMID: 24133105.
[24]	Protic D et al. Nosocomial coagulase-negative staphylococci in Belgrade: between Scylla and Charybdis. J Infect Dev Ctries. 2016 Sep 30; 10 (9): 907-912. doi: 10.3855/jidc.7939. PMID: 27694722.
[25]	Telenchana-Chimbo P, Barrera-Carmona C, Cevallos-Quintero E, et al. Prevalence of osteoarticular infections by Enterobacteria producing extended-spectrum β-lactamases. Acta Ortop Mex. 2019; 33 (4): 232-236.
[26]	Lorrot M, Gillet Y, Gras Le Guen C, Launay E, Cohen R, Grimprel E. Antibiotic therapy of bone and joint infections in children: proposals of the French Pediatric Infectious Disease Group. Arch Pediatr. 2017 Dec; 24 (12S): S36-S41. doi: 10.1016/S0929-693X(17)30517-1. PMID: 29290233.

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APA Style

Hajar Skali, Fatima Zahrae Lazrak, Asmae Lamrani Hanchi, Tarik Salama, El Mohtadi Aghoutane, et al. (2022). 11-year Surveillance of the Epidemiological and Bacteriological Profile of Osteoarticular Infections in Children. American Journal of Laboratory Medicine, 7(2), 23-27. https://doi.org/10.11648/j.ajlm.20220702.11

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ACS Style

Hajar Skali; Fatima Zahrae Lazrak; Asmae Lamrani Hanchi; Tarik Salama; El Mohtadi Aghoutane, et al. 11-year Surveillance of the Epidemiological and Bacteriological Profile of Osteoarticular Infections in Children. Am. J. Lab. Med. 2022, 7(2), 23-27. doi: 10.11648/j.ajlm.20220702.11

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AMA Style

Hajar Skali, Fatima Zahrae Lazrak, Asmae Lamrani Hanchi, Tarik Salama, El Mohtadi Aghoutane, et al. 11-year Surveillance of the Epidemiological and Bacteriological Profile of Osteoarticular Infections in Children. Am J Lab Med. 2022;7(2):23-27. doi: 10.11648/j.ajlm.20220702.11

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@article{10.11648/j.ajlm.20220702.11,
  author = {Hajar Skali and Fatima Zahrae Lazrak and Asmae Lamrani Hanchi and Tarik Salama and El Mohtadi Aghoutane and Redouane El Fezzazi and Nabila Soraa},
  title = {11-year Surveillance of the Epidemiological and Bacteriological Profile of Osteoarticular Infections in Children},
  journal = {American Journal of Laboratory Medicine},
  volume = {7},
  number = {2},
  pages = {23-27},
  doi = {10.11648/j.ajlm.20220702.11},
  url = {https://doi.org/10.11648/j.ajlm.20220702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20220702.11},
  abstract = {Osteoarticular infections are an important cause of morbidity and mortality in the pediatric age group. Staphylococcus aureus is the most frequently identified. Early adequate and multidisciplinary care is required. Recently, an increasing incidence of OAI has been related to the improvement of identification methods of microorganism. The aim of this study was to describe, over a period of 11 years, the epidemiological and bacteriological profile of pediatric osteoarticular infections. This retrospective study conducted at the Microbiology Department of the University Hospital of Marrakech over a period of 11 years (2010-2020) including all strains isolated from synovial fluid or bone or joint samples obtained from the pediatric orthopedic surgery department. Six hundred thirty-nine samples were analyzed. The positivity rate to bacteria was at 56,5%. The mean age was 6,5 years. The male gender was predominant with a sex-ratio at 2,65. Arthritis represented 60%. The main etiological agent was Staphylococcus aureus, followed by Streptococcus Beta hemolytic group A (13,3%). Strains of Enterobacteriaceae (EB) were resistant to third-generation cephalosporins by production of Extended Spectrum Betalactamase in 45% of cases. An early diagnosis and start of antimicrobial treatment are crucial for good patient outcome, as well as the control of the infectious focus. Cytobacteriological examination is essential in order to isolate the germ, to study its susceptibility to antibiotics.},
 year = {2022}
}

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TY - JOUR
T1 - 11-year Surveillance of the Epidemiological and Bacteriological Profile of Osteoarticular Infections in Children
AU - Hajar Skali
AU - Fatima Zahrae Lazrak
AU - Asmae Lamrani Hanchi
AU - Tarik Salama
AU - El Mohtadi Aghoutane
AU - Redouane El Fezzazi
AU - Nabila Soraa
Y1 - 2022/03/12
PY - 2022
N1 - https://doi.org/10.11648/j.ajlm.20220702.11
DO - 10.11648/j.ajlm.20220702.11
T2 - American Journal of Laboratory Medicine
JF - American Journal of Laboratory Medicine
JO - American Journal of Laboratory Medicine
SP - 23
EP - 27
PB - Science Publishing Group
SN - 2575-386X
UR - https://doi.org/10.11648/j.ajlm.20220702.11
AB - Osteoarticular infections are an important cause of morbidity and mortality in the pediatric age group. Staphylococcus aureus is the most frequently identified. Early adequate and multidisciplinary care is required. Recently, an increasing incidence of OAI has been related to the improvement of identification methods of microorganism. The aim of this study was to describe, over a period of 11 years, the epidemiological and bacteriological profile of pediatric osteoarticular infections. This retrospective study conducted at the Microbiology Department of the University Hospital of Marrakech over a period of 11 years (2010-2020) including all strains isolated from synovial fluid or bone or joint samples obtained from the pediatric orthopedic surgery department. Six hundred thirty-nine samples were analyzed. The positivity rate to bacteria was at 56,5%. The mean age was 6,5 years. The male gender was predominant with a sex-ratio at 2,65. Arthritis represented 60%. The main etiological agent was Staphylococcus aureus, followed by Streptococcus Beta hemolytic group A (13,3%). Strains of Enterobacteriaceae (EB) were resistant to third-generation cephalosporins by production of Extended Spectrum Betalactamase in 45% of cases. An early diagnosis and start of antimicrobial treatment are crucial for good patient outcome, as well as the control of the infectious focus. Cytobacteriological examination is essential in order to isolate the germ, to study its susceptibility to antibiotics.
VL - 7
IS - 2
ER -

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Author Information

Hajar Skali

Bacteriology-Virology Laboratory, Arrazi Hospital, University Hospital Mohammed VI of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, University of Cadi Ayyad of Marrakech, Marrakech, Morocco
Fatima Zahrae Lazrak

Bacteriology-Virology Laboratory, Arrazi Hospital, University Hospital Mohammed VI of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, University of Cadi Ayyad of Marrakech, Marrakech, Morocco
Asmae Lamrani Hanchi

Bacteriology-Virology Laboratory, Arrazi Hospital, University Hospital Mohammed VI of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, University of Cadi Ayyad of Marrakech, Marrakech, Morocco
Tarik Salama

Pediatric Orthopedics Department, Arrazi Hospital, University Hospital Mohammed VI of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, University of Cadi Ayyad of Marrakech, Marrakech, Morocco
El Mohtadi Aghoutane

Pediatric Orthopedics Department, Arrazi Hospital, University Hospital Mohammed VI of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, University of Cadi Ayyad of Marrakech, Marrakech, Morocco
Redouane El Fezzazi

Pediatric Orthopedics Department, Arrazi Hospital, University Hospital Mohammed VI of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, University of Cadi Ayyad of Marrakech, Marrakech, Morocco
Nabila Soraa

Bacteriology-Virology Laboratory, Arrazi Hospital, University Hospital Mohammed VI of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, University of Cadi Ayyad of Marrakech, Marrakech, Morocco

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APA Style

Hajar Skali, Fatima Zahrae Lazrak, Asmae Lamrani Hanchi, Tarik Salama, El Mohtadi Aghoutane, et al. (2022). 11-year Surveillance of the Epidemiological and Bacteriological Profile of Osteoarticular Infections in Children. American Journal of Laboratory Medicine, 7(2), 23-27. https://doi.org/10.11648/j.ajlm.20220702.11

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ACS Style

Hajar Skali; Fatima Zahrae Lazrak; Asmae Lamrani Hanchi; Tarik Salama; El Mohtadi Aghoutane, et al. 11-year Surveillance of the Epidemiological and Bacteriological Profile of Osteoarticular Infections in Children. Am. J. Lab. Med. 2022, 7(2), 23-27. doi: 10.11648/j.ajlm.20220702.11

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AMA Style

Hajar Skali, Fatima Zahrae Lazrak, Asmae Lamrani Hanchi, Tarik Salama, El Mohtadi Aghoutane, et al. 11-year Surveillance of the Epidemiological and Bacteriological Profile of Osteoarticular Infections in Children. Am J Lab Med. 2022;7(2):23-27. doi: 10.11648/j.ajlm.20220702.11

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@article{10.11648/j.ajlm.20220702.11,
  author = {Hajar Skali and Fatima Zahrae Lazrak and Asmae Lamrani Hanchi and Tarik Salama and El Mohtadi Aghoutane and Redouane El Fezzazi and Nabila Soraa},
  title = {11-year Surveillance of the Epidemiological and Bacteriological Profile of Osteoarticular Infections in Children},
  journal = {American Journal of Laboratory Medicine},
  volume = {7},
  number = {2},
  pages = {23-27},
  doi = {10.11648/j.ajlm.20220702.11},
  url = {https://doi.org/10.11648/j.ajlm.20220702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20220702.11},
  abstract = {Osteoarticular infections are an important cause of morbidity and mortality in the pediatric age group. Staphylococcus aureus is the most frequently identified. Early adequate and multidisciplinary care is required. Recently, an increasing incidence of OAI has been related to the improvement of identification methods of microorganism. The aim of this study was to describe, over a period of 11 years, the epidemiological and bacteriological profile of pediatric osteoarticular infections. This retrospective study conducted at the Microbiology Department of the University Hospital of Marrakech over a period of 11 years (2010-2020) including all strains isolated from synovial fluid or bone or joint samples obtained from the pediatric orthopedic surgery department. Six hundred thirty-nine samples were analyzed. The positivity rate to bacteria was at 56,5%. The mean age was 6,5 years. The male gender was predominant with a sex-ratio at 2,65. Arthritis represented 60%. The main etiological agent was Staphylococcus aureus, followed by Streptococcus Beta hemolytic group A (13,3%). Strains of Enterobacteriaceae (EB) were resistant to third-generation cephalosporins by production of Extended Spectrum Betalactamase in 45% of cases. An early diagnosis and start of antimicrobial treatment are crucial for good patient outcome, as well as the control of the infectious focus. Cytobacteriological examination is essential in order to isolate the germ, to study its susceptibility to antibiotics.},
 year = {2022}
}

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