Association of Lipid Ratios and Neutrophil-lymphocyte Ratio in Type 2 Diabetic Moroccan Patients Without Chronic Kidney Disease

Siham Aboulmakarim; Abderrahmane Boukhira; Sanae Sayagh; Saliha Chellak

doi:doi:10.11648/j.ajlm.20210606.15

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Association of Lipid Ratios and Neutrophil-lymphocyte Ratio in Type 2 Diabetic Moroccan Patients Without Chronic Kidney Disease

Siham Aboulmakarim, Abderrahmane Boukhira, Sanae Sayagh, Saliha Chellak

Published in American Journal of Laboratory Medicine (Volume 6, Issue 6)

Received: 10 November 2021 Accepted: 30 November 2021 Published: 24 December 2021

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Abstract

Background: Atherogenic dyslipidemia and currently chronic inflammation are among the factors of atherosclerosis in type 2 diabetes mellitus patients (T2DM). This retrospective study conducted at Mohammed VI University Hospital, Morocco, from January 2020 to June 2021, aimed to investigate the association between the lipid profile, lipid ratios and neutrophil to lymphocyte ratio (NLR), among T2DM Moroccan patients without chronic kidney disease and to find out the possible correlation between these parameters and glycated hemoglobin (HbA1c). Methods: 274 T2DM patients and 88 non-diabetic controls aged over 40 years old were analyzed. Fasting plasma glucose, lipid profile tests, liver and renal function tests, and HbA1c test were measured. The NLR and lipid ratios including total cholesterol / HDL-c, non- HDL-c and atherogenic index of plasma were calculated. Results: There was no significant difference in median level of all lipid profile parameters between the poor controlled T2DM group (HbA1c > 7%) compared to the well controlled group (HbA1c ≤ 7%) and control group (all P > 0.05). All lipid ratios were lower in the good controlled group compared to the poor controlled diabetes group, but the difference did not reach statistical significance (all P > 0.05). HbA1c was correlated with FPG, and neutrophils (r = 0.655, r = 0.263, P < 0.001 respectively). NLR was weekly correlated with HDL (r = -0.14, P = 0.01). By using multivariate logistic regression, FPG was the only factor significantly predictive of well diabetic control. Conclusion: This study did not show significant association between HbA1c, lipid ratios and NLR.

Published in	American Journal of Laboratory Medicine (Volume 6, Issue 6)
DOI	10.11648/j.ajlm.20210606.15
Page(s)	107-113
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Diabetes Mellitus Type 2, Lipid Ratios, Neutrophil-to-lymphocyte ratio, Glycated Hemoglobin, Morocco

References

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APA Style

Siham Aboulmakarim, Abderrahmane Boukhira, Sanae Sayagh, Saliha Chellak. (2021). Association of Lipid Ratios and Neutrophil-lymphocyte Ratio in Type 2 Diabetic Moroccan Patients Without Chronic Kidney Disease. American Journal of Laboratory Medicine, 6(6), 107-113. https://doi.org/10.11648/j.ajlm.20210606.15

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ACS Style

Siham Aboulmakarim; Abderrahmane Boukhira; Sanae Sayagh; Saliha Chellak. Association of Lipid Ratios and Neutrophil-lymphocyte Ratio in Type 2 Diabetic Moroccan Patients Without Chronic Kidney Disease. Am. J. Lab. Med. 2021, 6(6), 107-113. doi: 10.11648/j.ajlm.20210606.15

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AMA Style

Siham Aboulmakarim, Abderrahmane Boukhira, Sanae Sayagh, Saliha Chellak. Association of Lipid Ratios and Neutrophil-lymphocyte Ratio in Type 2 Diabetic Moroccan Patients Without Chronic Kidney Disease. Am J Lab Med. 2021;6(6):107-113. doi: 10.11648/j.ajlm.20210606.15

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@article{10.11648/j.ajlm.20210606.15,
  author = {Siham Aboulmakarim and Abderrahmane Boukhira and Sanae Sayagh and Saliha Chellak},
  title = {Association of Lipid Ratios and Neutrophil-lymphocyte Ratio in Type 2 Diabetic Moroccan Patients Without Chronic Kidney Disease},
  journal = {American Journal of Laboratory Medicine},
  volume = {6},
  number = {6},
  pages = {107-113},
  doi = {10.11648/j.ajlm.20210606.15},
  url = {https://doi.org/10.11648/j.ajlm.20210606.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20210606.15},
  abstract = {Background: Atherogenic dyslipidemia and currently chronic inflammation are among the factors of atherosclerosis in type 2 diabetes mellitus patients (T2DM). This retrospective study conducted at Mohammed VI University Hospital, Morocco, from January 2020 to June 2021, aimed to investigate the association between the lipid profile, lipid ratios and neutrophil to lymphocyte ratio (NLR), among T2DM Moroccan patients without chronic kidney disease and to find out the possible correlation between these parameters and glycated hemoglobin (HbA1c). Methods: 274 T2DM patients and 88 non-diabetic controls aged over 40 years old were analyzed. Fasting plasma glucose, lipid profile tests, liver and renal function tests, and HbA1c test were measured. The NLR and lipid ratios including total cholesterol / HDL-c, non- HDL-c and atherogenic index of plasma were calculated. Results: There was no significant difference in median level of all lipid profile parameters between the poor controlled T2DM group (HbA1c > 7%) compared to the well controlled group (HbA1c ≤ 7%) and control group (all P > 0.05). All lipid ratios were lower in the good controlled group compared to the poor controlled diabetes group, but the difference did not reach statistical significance (all P > 0.05). HbA1c was correlated with FPG, and neutrophils (r = 0.655, r = 0.263, P P = 0.01). By using multivariate logistic regression, FPG was the only factor significantly predictive of well diabetic control. Conclusion: This study did not show significant association between HbA1c, lipid ratios and NLR.},
 year = {2021}
}

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TY  - JOUR
T1  - Association of Lipid Ratios and Neutrophil-lymphocyte Ratio in Type 2 Diabetic Moroccan Patients Without Chronic Kidney Disease
AU  - Siham Aboulmakarim
AU  - Abderrahmane Boukhira
AU  - Sanae Sayagh
AU  - Saliha Chellak
Y1  - 2021/12/24
PY  - 2021
N1  - https://doi.org/10.11648/j.ajlm.20210606.15
DO  - 10.11648/j.ajlm.20210606.15
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 107
EP  - 113
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20210606.15
AB  - Background: Atherogenic dyslipidemia and currently chronic inflammation are among the factors of atherosclerosis in type 2 diabetes mellitus patients (T2DM). This retrospective study conducted at Mohammed VI University Hospital, Morocco, from January 2020 to June 2021, aimed to investigate the association between the lipid profile, lipid ratios and neutrophil to lymphocyte ratio (NLR), among T2DM Moroccan patients without chronic kidney disease and to find out the possible correlation between these parameters and glycated hemoglobin (HbA1c). Methods: 274 T2DM patients and 88 non-diabetic controls aged over 40 years old were analyzed. Fasting plasma glucose, lipid profile tests, liver and renal function tests, and HbA1c test were measured. The NLR and lipid ratios including total cholesterol / HDL-c, non- HDL-c and atherogenic index of plasma were calculated. Results: There was no significant difference in median level of all lipid profile parameters between the poor controlled T2DM group (HbA1c > 7%) compared to the well controlled group (HbA1c ≤ 7%) and control group (all P > 0.05). All lipid ratios were lower in the good controlled group compared to the poor controlled diabetes group, but the difference did not reach statistical significance (all P > 0.05). HbA1c was correlated with FPG, and neutrophils (r = 0.655, r = 0.263, P P = 0.01). By using multivariate logistic regression, FPG was the only factor significantly predictive of well diabetic control. Conclusion: This study did not show significant association between HbA1c, lipid ratios and NLR.
VL  - 6
IS  - 6
ER  -

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Author Information

Siham Aboulmakarim

Department of Biochemistry, Arrazi Hospital, Mohamed VI Medical Center, Marrakech, Morocco
Abderrahmane Boukhira

Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University, Marrakech, Morocco
Sanae Sayagh

Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University, Marrakech, Morocco
Saliha Chellak

Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University, Marrakech, Morocco

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Siham Aboulmakarim, Abderrahmane Boukhira, Sanae Sayagh, Saliha Chellak. (2021). Association of Lipid Ratios and Neutrophil-lymphocyte Ratio in Type 2 Diabetic Moroccan Patients Without Chronic Kidney Disease. American Journal of Laboratory Medicine, 6(6), 107-113. https://doi.org/10.11648/j.ajlm.20210606.15

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ACS Style

Siham Aboulmakarim; Abderrahmane Boukhira; Sanae Sayagh; Saliha Chellak. Association of Lipid Ratios and Neutrophil-lymphocyte Ratio in Type 2 Diabetic Moroccan Patients Without Chronic Kidney Disease. Am. J. Lab. Med. 2021, 6(6), 107-113. doi: 10.11648/j.ajlm.20210606.15

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AMA Style

Siham Aboulmakarim, Abderrahmane Boukhira, Sanae Sayagh, Saliha Chellak. Association of Lipid Ratios and Neutrophil-lymphocyte Ratio in Type 2 Diabetic Moroccan Patients Without Chronic Kidney Disease. Am J Lab Med. 2021;6(6):107-113. doi: 10.11648/j.ajlm.20210606.15

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@article{10.11648/j.ajlm.20210606.15,
  author = {Siham Aboulmakarim and Abderrahmane Boukhira and Sanae Sayagh and Saliha Chellak},
  title = {Association of Lipid Ratios and Neutrophil-lymphocyte Ratio in Type 2 Diabetic Moroccan Patients Without Chronic Kidney Disease},
  journal = {American Journal of Laboratory Medicine},
  volume = {6},
  number = {6},
  pages = {107-113},
  doi = {10.11648/j.ajlm.20210606.15},
  url = {https://doi.org/10.11648/j.ajlm.20210606.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20210606.15},
  abstract = {Background: Atherogenic dyslipidemia and currently chronic inflammation are among the factors of atherosclerosis in type 2 diabetes mellitus patients (T2DM). This retrospective study conducted at Mohammed VI University Hospital, Morocco, from January 2020 to June 2021, aimed to investigate the association between the lipid profile, lipid ratios and neutrophil to lymphocyte ratio (NLR), among T2DM Moroccan patients without chronic kidney disease and to find out the possible correlation between these parameters and glycated hemoglobin (HbA1c). Methods: 274 T2DM patients and 88 non-diabetic controls aged over 40 years old were analyzed. Fasting plasma glucose, lipid profile tests, liver and renal function tests, and HbA1c test were measured. The NLR and lipid ratios including total cholesterol / HDL-c, non- HDL-c and atherogenic index of plasma were calculated. Results: There was no significant difference in median level of all lipid profile parameters between the poor controlled T2DM group (HbA1c > 7%) compared to the well controlled group (HbA1c ≤ 7%) and control group (all P > 0.05). All lipid ratios were lower in the good controlled group compared to the poor controlled diabetes group, but the difference did not reach statistical significance (all P > 0.05). HbA1c was correlated with FPG, and neutrophils (r = 0.655, r = 0.263, P P = 0.01). By using multivariate logistic regression, FPG was the only factor significantly predictive of well diabetic control. Conclusion: This study did not show significant association between HbA1c, lipid ratios and NLR.},
 year = {2021}
}

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TY  - JOUR
T1  - Association of Lipid Ratios and Neutrophil-lymphocyte Ratio in Type 2 Diabetic Moroccan Patients Without Chronic Kidney Disease
AU  - Siham Aboulmakarim
AU  - Abderrahmane Boukhira
AU  - Sanae Sayagh
AU  - Saliha Chellak
Y1  - 2021/12/24
PY  - 2021
N1  - https://doi.org/10.11648/j.ajlm.20210606.15
DO  - 10.11648/j.ajlm.20210606.15
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 107
EP  - 113
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20210606.15
AB  - Background: Atherogenic dyslipidemia and currently chronic inflammation are among the factors of atherosclerosis in type 2 diabetes mellitus patients (T2DM). This retrospective study conducted at Mohammed VI University Hospital, Morocco, from January 2020 to June 2021, aimed to investigate the association between the lipid profile, lipid ratios and neutrophil to lymphocyte ratio (NLR), among T2DM Moroccan patients without chronic kidney disease and to find out the possible correlation between these parameters and glycated hemoglobin (HbA1c). Methods: 274 T2DM patients and 88 non-diabetic controls aged over 40 years old were analyzed. Fasting plasma glucose, lipid profile tests, liver and renal function tests, and HbA1c test were measured. The NLR and lipid ratios including total cholesterol / HDL-c, non- HDL-c and atherogenic index of plasma were calculated. Results: There was no significant difference in median level of all lipid profile parameters between the poor controlled T2DM group (HbA1c > 7%) compared to the well controlled group (HbA1c ≤ 7%) and control group (all P > 0.05). All lipid ratios were lower in the good controlled group compared to the poor controlled diabetes group, but the difference did not reach statistical significance (all P > 0.05). HbA1c was correlated with FPG, and neutrophils (r = 0.655, r = 0.263, P P = 0.01). By using multivariate logistic regression, FPG was the only factor significantly predictive of well diabetic control. Conclusion: This study did not show significant association between HbA1c, lipid ratios and NLR.
VL  - 6
IS  - 6
ER  -

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