Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report

Asmell Ramos Cabrera; Alexis Culay Perez; Yamila Rodriguez Sanchez; Alexis Gregori Caballero

doi:doi:10.11648/j.ajlm.20210606.12

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Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report

Asmell Ramos Cabrera, Alexis Culay Perez, Yamila Rodriguez Sanchez, Alexis Gregori Caballero

Published in American Journal of Laboratory Medicine (Volume 6, Issue 6)

Received: 6 June 2021 Accepted: 7 July 2021 Published: 23 November 2021

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Abstract

Hoffmann syndrome is defined since 1897 as the combination of hypothyroidism with myopathy, mioedema, rigidity, muscle cramps, and hypertrophy. The objective of this publication is to describe a typical case of thyroid disease with clinical, hormonal, and muscular characteristics of a Hoffmann syndrome, as an exceptional manifestation of hypothyroidism. The clinical challenge consisted in linking the apparent ambiguity of the clinical symptoms such as: generalized weakness, fatigue, muscle cramps in a young patient, without personal record of previous disease, apparently healthy and well-nourished with favorable muscle development. Additionally, manifestation of pituitary gland dysfunction was found, such as headache and galactorrhea, bibliography reviewed showed mainly, male patients patter and not any comment concerning hypophysis impairment. all clinical manifestations disappeared after replacement treatment with levothyroxine, including the goiter and pituitary macroadenoma. The management of the case involved a multidisciplinary team and involved internists, cardiologist, endocrinologists, radiologist, and neurosurgeons. This form of thyroid myopathy is rare and usually accompanies adult patients with severe and long-standing hypothyroidism, is different from those that begin in early childhood and are associated with cretinism and muscle hypertrophy.

Published in	American Journal of Laboratory Medicine (Volume 6, Issue 6)
DOI	10.11648/j.ajlm.20210606.12
Page(s)	88-90
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hoffmann Syndrome, Hypothyroidism, Myopathy

References

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[12]	Peioxoto Kades MG, Silvano de Aquino ME, Pereira de Souza L. WerdnigHoffman syndrome: pathological aspects and knowledge of the disease. Recien Magazine [Internet].2017 [cited 2019 Mar 12]; 7 (20): [approx. 8p.]. Available at: https://www.recien.com.br/index.php/Recien/article/download/224/pdf_1http://revistaamc.sld.cu/
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APA Style

Asmell Ramos Cabrera, Alexis Culay Perez, Yamila Rodriguez Sanchez, Alexis Gregori Caballero. (2021). Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report. American Journal of Laboratory Medicine, 6(6), 88-90. https://doi.org/10.11648/j.ajlm.20210606.12

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ACS Style

Asmell Ramos Cabrera; Alexis Culay Perez; Yamila Rodriguez Sanchez; Alexis Gregori Caballero. Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report. Am. J. Lab. Med. 2021, 6(6), 88-90. doi: 10.11648/j.ajlm.20210606.12

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AMA Style

Asmell Ramos Cabrera, Alexis Culay Perez, Yamila Rodriguez Sanchez, Alexis Gregori Caballero. Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report. Am J Lab Med. 2021;6(6):88-90. doi: 10.11648/j.ajlm.20210606.12

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@article{10.11648/j.ajlm.20210606.12,
  author = {Asmell Ramos Cabrera and Alexis Culay Perez and Yamila Rodriguez Sanchez and Alexis Gregori Caballero},
  title = {Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report},
  journal = {American Journal of Laboratory Medicine},
  volume = {6},
  number = {6},
  pages = {88-90},
  doi = {10.11648/j.ajlm.20210606.12},
  url = {https://doi.org/10.11648/j.ajlm.20210606.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20210606.12},
  abstract = {Hoffmann syndrome is defined since 1897 as the combination of hypothyroidism with myopathy, mioedema, rigidity, muscle cramps, and hypertrophy. The objective of this publication is to describe a typical case of thyroid disease with clinical, hormonal, and muscular characteristics of a Hoffmann syndrome, as an exceptional manifestation of hypothyroidism. The clinical challenge consisted in linking the apparent ambiguity of the clinical symptoms such as: generalized weakness, fatigue, muscle cramps in a young patient, without personal record of previous disease, apparently healthy and well-nourished with favorable muscle development. Additionally, manifestation of pituitary gland dysfunction was found, such as headache and galactorrhea, bibliography reviewed showed mainly, male patients patter and not any comment concerning hypophysis impairment. all clinical manifestations disappeared after replacement treatment with levothyroxine, including the goiter and pituitary macroadenoma. The management of the case involved a multidisciplinary team and involved internists, cardiologist, endocrinologists, radiologist, and neurosurgeons. This form of thyroid myopathy is rare and usually accompanies adult patients with severe and long-standing hypothyroidism, is different from those that begin in early childhood and are associated with cretinism and muscle hypertrophy.},
 year = {2021}
}

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TY  - JOUR
T1  - Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report
AU  - Asmell Ramos Cabrera
AU  - Alexis Culay Perez
AU  - Yamila Rodriguez Sanchez
AU  - Alexis Gregori Caballero
Y1  - 2021/11/23
PY  - 2021
N1  - https://doi.org/10.11648/j.ajlm.20210606.12
DO  - 10.11648/j.ajlm.20210606.12
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 88
EP  - 90
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20210606.12
AB  - Hoffmann syndrome is defined since 1897 as the combination of hypothyroidism with myopathy, mioedema, rigidity, muscle cramps, and hypertrophy. The objective of this publication is to describe a typical case of thyroid disease with clinical, hormonal, and muscular characteristics of a Hoffmann syndrome, as an exceptional manifestation of hypothyroidism. The clinical challenge consisted in linking the apparent ambiguity of the clinical symptoms such as: generalized weakness, fatigue, muscle cramps in a young patient, without personal record of previous disease, apparently healthy and well-nourished with favorable muscle development. Additionally, manifestation of pituitary gland dysfunction was found, such as headache and galactorrhea, bibliography reviewed showed mainly, male patients patter and not any comment concerning hypophysis impairment. all clinical manifestations disappeared after replacement treatment with levothyroxine, including the goiter and pituitary macroadenoma. The management of the case involved a multidisciplinary team and involved internists, cardiologist, endocrinologists, radiologist, and neurosurgeons. This form of thyroid myopathy is rare and usually accompanies adult patients with severe and long-standing hypothyroidism, is different from those that begin in early childhood and are associated with cretinism and muscle hypertrophy.
VL  - 6
IS  - 6
ER  -

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Author Information

Asmell Ramos Cabrera

Internal Medicine Department, American International University West Africa, Banjul, Gambia
Alexis Culay Perez

Internal Medicine Department, Manuel Ascunce D teaching Hospital, Camaguey, Cuba
Yamila Rodriguez Sanchez

Internal Medicine Department, Manuel Ascunce D teaching Hospital, Camaguey, Cuba
Alexis Gregori Caballero

Internal Medicine Department, Manuel Ascunce D teaching Hospital, Camaguey, Cuba

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Plain Text BibTeX RIS

APA Style

Asmell Ramos Cabrera, Alexis Culay Perez, Yamila Rodriguez Sanchez, Alexis Gregori Caballero. (2021). Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report. American Journal of Laboratory Medicine, 6(6), 88-90. https://doi.org/10.11648/j.ajlm.20210606.12

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ACS Style

Asmell Ramos Cabrera; Alexis Culay Perez; Yamila Rodriguez Sanchez; Alexis Gregori Caballero. Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report. Am. J. Lab. Med. 2021, 6(6), 88-90. doi: 10.11648/j.ajlm.20210606.12

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AMA Style

Asmell Ramos Cabrera, Alexis Culay Perez, Yamila Rodriguez Sanchez, Alexis Gregori Caballero. Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report. Am J Lab Med. 2021;6(6):88-90. doi: 10.11648/j.ajlm.20210606.12

Copy | Download

@article{10.11648/j.ajlm.20210606.12,
  author = {Asmell Ramos Cabrera and Alexis Culay Perez and Yamila Rodriguez Sanchez and Alexis Gregori Caballero},
  title = {Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report},
  journal = {American Journal of Laboratory Medicine},
  volume = {6},
  number = {6},
  pages = {88-90},
  doi = {10.11648/j.ajlm.20210606.12},
  url = {https://doi.org/10.11648/j.ajlm.20210606.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20210606.12},
  abstract = {Hoffmann syndrome is defined since 1897 as the combination of hypothyroidism with myopathy, mioedema, rigidity, muscle cramps, and hypertrophy. The objective of this publication is to describe a typical case of thyroid disease with clinical, hormonal, and muscular characteristics of a Hoffmann syndrome, as an exceptional manifestation of hypothyroidism. The clinical challenge consisted in linking the apparent ambiguity of the clinical symptoms such as: generalized weakness, fatigue, muscle cramps in a young patient, without personal record of previous disease, apparently healthy and well-nourished with favorable muscle development. Additionally, manifestation of pituitary gland dysfunction was found, such as headache and galactorrhea, bibliography reviewed showed mainly, male patients patter and not any comment concerning hypophysis impairment. all clinical manifestations disappeared after replacement treatment with levothyroxine, including the goiter and pituitary macroadenoma. The management of the case involved a multidisciplinary team and involved internists, cardiologist, endocrinologists, radiologist, and neurosurgeons. This form of thyroid myopathy is rare and usually accompanies adult patients with severe and long-standing hypothyroidism, is different from those that begin in early childhood and are associated with cretinism and muscle hypertrophy.},
 year = {2021}
}

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TY  - JOUR
T1  - Hoffmann Syndrome, Manifestation of Hypothyroidism: Case Report
AU  - Asmell Ramos Cabrera
AU  - Alexis Culay Perez
AU  - Yamila Rodriguez Sanchez
AU  - Alexis Gregori Caballero
Y1  - 2021/11/23
PY  - 2021
N1  - https://doi.org/10.11648/j.ajlm.20210606.12
DO  - 10.11648/j.ajlm.20210606.12
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 88
EP  - 90
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20210606.12
AB  - Hoffmann syndrome is defined since 1897 as the combination of hypothyroidism with myopathy, mioedema, rigidity, muscle cramps, and hypertrophy. The objective of this publication is to describe a typical case of thyroid disease with clinical, hormonal, and muscular characteristics of a Hoffmann syndrome, as an exceptional manifestation of hypothyroidism. The clinical challenge consisted in linking the apparent ambiguity of the clinical symptoms such as: generalized weakness, fatigue, muscle cramps in a young patient, without personal record of previous disease, apparently healthy and well-nourished with favorable muscle development. Additionally, manifestation of pituitary gland dysfunction was found, such as headache and galactorrhea, bibliography reviewed showed mainly, male patients patter and not any comment concerning hypophysis impairment. all clinical manifestations disappeared after replacement treatment with levothyroxine, including the goiter and pituitary macroadenoma. The management of the case involved a multidisciplinary team and involved internists, cardiologist, endocrinologists, radiologist, and neurosurgeons. This form of thyroid myopathy is rare and usually accompanies adult patients with severe and long-standing hypothyroidism, is different from those that begin in early childhood and are associated with cretinism and muscle hypertrophy.
VL  - 6
IS  - 6
ER  -

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