Bone marrow examination is a vital study carried out to attain a positive diagnosis of hematological disorders in a resource low income country like Nigeria specifically in Ondo state. Bone marrow is a main spot of hematopoiesis. It is also a major tool used in diagnosis of non-hematological disorders. The main aim of this study is to examine the outcome of bone marrow aspiration in Ondo state. A retrospective 8 years study was carried out between 2012 till 2020 at the University of medical sciences (former Kidney care center, Trauma center and State specialist hospital, Akure) Ondo state. Age, sex, location of patients, bleeding disorders, various indications and diagnosis were analysed using SPSS version 23. A total of 115 bone marrow aspirations were done at University of medical sciences, Ondo. Majority of the patients were male (58.3%) while 41.7% were females. Most are aged above 45 (46.1%). The most common indication was Anaemia specifically the moderate anaemia (52.2%). Commonest diagnostic findings in our study was Leukemia (42%) followed by Megaloblastic anaemia and Multiple myeloma (12.1%). Given the increase in the prevalence of Megaloblastic anaemia and Iron deficiency anemia globally, our study showed high prevalence rate of leukemia specifically chronic myeloid leukemia. The predominance of leukemia among diagnostic findings in our study has been related to the proximity to tertiary health facility. Low number of cases of other diagnostic findings can be due to lack of accessibility to an improved health center especially those in the rural areas and low population of people in the state. Early diagnosis should be done for effective management of these hematological disorders. Good family support and improved health care system with well trained personnel will help in management of the disease.
| Published in | American Journal of Laboratory Medicine (Volume 6, Issue 2) |
| DOI | 10.11648/j.ajlm.20210602.11 |
| Page(s) | 17-21 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Hematological Disorders, Hematopoiesis, Bone Marrow Examination, Megaloblastic Anaemia, Multiple Myeloma
| [1] | Gohil M, Rathod K. Bone Marrow Aspiration Cytology Study in a Tertiary Care Center, Gujarat, India. Int J Sci Stud 2018; 5 (10): 11-14. |
| [2] | Gluckman E. Choice of the donor according to HLA typing and stem cell source. In: Apperley J, Carreras E, Gluckman E, Masszi T, editors. EBMT Handbook Haemotopoietic Stem cell Transplantation. 6th ed., Vol. 6. Nigeria: EBMT Handbook; 2012. p. 90-107. |
| [3] | Catovsky D, Tuddenham E, editors. Postgraduate Haematology. 6th ed. Massachusetts USA: Blackwell Publishers Ltd; 2011. pp 1-11. |
| [4] | Rock WA Jr., Stass SA, editors. Handbook of Hematologic Pathology. New York, NY: Marcel Dekker, Inc.; 2000. p. 1-26. |
| [5] | Ryan DH, Felgar RE. Examination of the marrow. In: Lichtman MA, Kipps TJ, et al (eds). William’s haematology 7ed. New York, McGraw Hill 2006; 3: 21-31. |
| [6] | Lee SH, Erber WN, Porwit A, et al: ICSH guidelines for the standardization of bone marrow specimens and reports. Int J Lab Hematol 2008; 30: 349 – 364. |
| [7] | Bain BJ. Bone marrow biopsy morbidity: Review of 2003. J Clin Pathol 2005; 58: 406-8. |
| [8] | Abla O, Friedman J, Doyle J. Performing bone marrow aspiration and biopsy in children: Recommended guidelines. Paediatr Child Health 2008; 13 (6): 499 – 501. |
| [9] | Halim NKD, Famodu AA, Wemanbu SNC. Textbook of Clinical Haematology and Immunology. Indications for bone marrow aspiration. 2nd Edition, Ambik Press; 2001: 10. |
| [10] | Bashawri LA. Bone marrow examination. Indications and diagnostic value. Saudi Med J 2002; 23: 191-6. |
| [11] | Egesie OJ, Joseph DE, Egesie UG, Ewuga JO. Epidemiology of anaemia necessityating bone marrow aspiration cytology in Jos. Niger Med J 2009; 50: 61-3. |
| [12] | Kaferle J, Strzoda C (2009). Evaluation of macrocytosis. Am. Fam. Physician. Pp. 203-208. |
| [13] | Berber I, Erkurt MA, Kuku I, et al. An unexpected complication of Bone Marrow Aspiration and Trephine Biopsy: Arteriovenous Fistula. Med Princ Pract 2014; 223: 280-383. |
| [14] | Vanhelleputte P, Nijs K, Delforge M, Evers G, Vanderschueren S. Pain during bone marrow aspiration: prevalence and prevention. J Pain Symptom Manage 2003; 26 (3): 860-6. |
| [15] | Damulak OD, Damen JG. Diagnostic outcome of Bone marrow aspiration in a new centre in Nigeria. Glob Adv Res J Med Med Sci 2012; 1: 166-71. |
| [16] | Dachi AF, Mustapha FG, Yuguda S, Kagu MB, Gwaram AA and Bwala P. Bone marrow aspiration cytology in Abubakar. |
| [17] | Khan SP, Sajjad G, Shareefa A, et al. Bone marrow aspiration in haematological disorders: study at a tertiary care centre. Int J Res Med Sci 2018; 6: 2363. |
| [18] | Adewoyin AS, Ezire ES, Adeyemi O, et al. Bone marrow aspiration cytology studies in a Tertiary Hospital Nigeria: A series of 88 cases. Ann Pathol Lab Med 2015; 2: 107-14. |
| [19] | Erkurt MA, Kaya E, Berber I, Koroglu M and Kuku I. Thrombocytopenia in Adults. J Hematol, 2012; 1 (2-3); 44-53. |
| [20] | Mahabir KV, Ross C, Popovis S, Sur ML et al. A blinded study of bone marrow examinations in patients with primary immune thrombocytopenia. Eur J Hematol. 2012. Available from https://doi.org/10.1111/ejh.12041 |
| [21] | Awwalu S, Haasan A, Dogara LG, Musa AU, Waziri AD, Babadoko AA. Bone marrow aspiration in Zaria: A Three-year retrospective review. Bo Med J 2016; 13 (1): 50-55. |
| [22] | Pudasaini S, Prasad KB, Rauniyar SK, Shrestha R, Gautaam K, Pathak R, et al. Interpretation of bone marrow aspiration in haematological disorders. J Pathol Nepal 2012; 2: 309-12. |
| [23] | Pierini M, Di Bella C, Dozza B, Frisoni T, Martella E, Belloti C, Remondini D, Lucarelli E, Giannini S, Donati D. The posterior iliac crest outperforms the anterior iliac crest when obtaining mesenchymal stem cells from the bone marrow. J Bone Joint Surg Am. 2013 Jun 19; 95 (12): 1101-7. |
| [24] | Thieml H, Diem H, Haferlach T (eds). Procedures, Assays and Normal values. In: Color Atlas of hematology. Practical microscopic and clinical diagnosis. Thieme Stuttgart New York. 2ed, 2002; 2: 9–28. |
| [25] | Fatima A and Ahmed IM. Diagnostic Outcome of Bone Marrow Aspiration in a Paediatric Centre in Hyderabad, India. 2018. JMSCR Vol 06 Issue 02 Page 1029-1037. |
| [26] | Mussarat N, Raziq F. The incidence of underlying pathology in pan cytopenia. An experience of 89 cases. J Postgrad Med Inst 2004; 18: 76-9. |
| [27] | Ng SC, Kuperan P, Chan KS, Bosco J, Chan GL. Megaloblastic anaemia – A review from University Hospital, Kuala Lumpur. Ann Acad Med Singapore 1988; 17: 261-6. |
| [28] | Akaba K, Enang O, Igwilo H, Eduve V, Akaba E, Cletus O, Oshatuyi O. Demographic pattern of chronic lymphocytic leukemia in a tertiary hospital in Calabar, South-South Nigeria. Ann Afr Med 2020; 19: 203-6. |
APA Style
Patrick Olanrewaju Osho, Maltida Adesuwa Ojo, Victor Koledoye, Aisha Ndidi Okunnuga, Oluwatosin Idowu Oni. (2021). Diagnostic Outcome of Bone Marrow Aspiration in a Tertiary Hospital in Ondo State, Nigeria. American Journal of Laboratory Medicine, 6(2), 17-21. https://doi.org/10.11648/j.ajlm.20210602.11
ACS Style
Patrick Olanrewaju Osho; Maltida Adesuwa Ojo; Victor Koledoye; Aisha Ndidi Okunnuga; Oluwatosin Idowu Oni. Diagnostic Outcome of Bone Marrow Aspiration in a Tertiary Hospital in Ondo State, Nigeria. Am. J. Lab. Med. 2021, 6(2), 17-21. doi: 10.11648/j.ajlm.20210602.11
AMA Style
Patrick Olanrewaju Osho, Maltida Adesuwa Ojo, Victor Koledoye, Aisha Ndidi Okunnuga, Oluwatosin Idowu Oni. Diagnostic Outcome of Bone Marrow Aspiration in a Tertiary Hospital in Ondo State, Nigeria. Am J Lab Med. 2021;6(2):17-21. doi: 10.11648/j.ajlm.20210602.11
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ajlm.20210602.11,
author = {Patrick Olanrewaju Osho and Maltida Adesuwa Ojo and Victor Koledoye and Aisha Ndidi Okunnuga and Oluwatosin Idowu Oni},
title = {Diagnostic Outcome of Bone Marrow Aspiration in a Tertiary Hospital in Ondo State, Nigeria},
journal = {American Journal of Laboratory Medicine},
volume = {6},
number = {2},
pages = {17-21},
doi = {10.11648/j.ajlm.20210602.11},
url = {https://doi.org/10.11648/j.ajlm.20210602.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20210602.11},
abstract = {Bone marrow examination is a vital study carried out to attain a positive diagnosis of hematological disorders in a resource low income country like Nigeria specifically in Ondo state. Bone marrow is a main spot of hematopoiesis. It is also a major tool used in diagnosis of non-hematological disorders. The main aim of this study is to examine the outcome of bone marrow aspiration in Ondo state. A retrospective 8 years study was carried out between 2012 till 2020 at the University of medical sciences (former Kidney care center, Trauma center and State specialist hospital, Akure) Ondo state. Age, sex, location of patients, bleeding disorders, various indications and diagnosis were analysed using SPSS version 23. A total of 115 bone marrow aspirations were done at University of medical sciences, Ondo. Majority of the patients were male (58.3%) while 41.7% were females. Most are aged above 45 (46.1%). The most common indication was Anaemia specifically the moderate anaemia (52.2%). Commonest diagnostic findings in our study was Leukemia (42%) followed by Megaloblastic anaemia and Multiple myeloma (12.1%). Given the increase in the prevalence of Megaloblastic anaemia and Iron deficiency anemia globally, our study showed high prevalence rate of leukemia specifically chronic myeloid leukemia. The predominance of leukemia among diagnostic findings in our study has been related to the proximity to tertiary health facility. Low number of cases of other diagnostic findings can be due to lack of accessibility to an improved health center especially those in the rural areas and low population of people in the state. Early diagnosis should be done for effective management of these hematological disorders. Good family support and improved health care system with well trained personnel will help in management of the disease.},
year = {2021}
}
TY - JOUR T1 - Diagnostic Outcome of Bone Marrow Aspiration in a Tertiary Hospital in Ondo State, Nigeria AU - Patrick Olanrewaju Osho AU - Maltida Adesuwa Ojo AU - Victor Koledoye AU - Aisha Ndidi Okunnuga AU - Oluwatosin Idowu Oni Y1 - 2021/04/12 PY - 2021 N1 - https://doi.org/10.11648/j.ajlm.20210602.11 DO - 10.11648/j.ajlm.20210602.11 T2 - American Journal of Laboratory Medicine JF - American Journal of Laboratory Medicine JO - American Journal of Laboratory Medicine SP - 17 EP - 21 PB - Science Publishing Group SN - 2575-386X UR - https://doi.org/10.11648/j.ajlm.20210602.11 AB - Bone marrow examination is a vital study carried out to attain a positive diagnosis of hematological disorders in a resource low income country like Nigeria specifically in Ondo state. Bone marrow is a main spot of hematopoiesis. It is also a major tool used in diagnosis of non-hematological disorders. The main aim of this study is to examine the outcome of bone marrow aspiration in Ondo state. A retrospective 8 years study was carried out between 2012 till 2020 at the University of medical sciences (former Kidney care center, Trauma center and State specialist hospital, Akure) Ondo state. Age, sex, location of patients, bleeding disorders, various indications and diagnosis were analysed using SPSS version 23. A total of 115 bone marrow aspirations were done at University of medical sciences, Ondo. Majority of the patients were male (58.3%) while 41.7% were females. Most are aged above 45 (46.1%). The most common indication was Anaemia specifically the moderate anaemia (52.2%). Commonest diagnostic findings in our study was Leukemia (42%) followed by Megaloblastic anaemia and Multiple myeloma (12.1%). Given the increase in the prevalence of Megaloblastic anaemia and Iron deficiency anemia globally, our study showed high prevalence rate of leukemia specifically chronic myeloid leukemia. The predominance of leukemia among diagnostic findings in our study has been related to the proximity to tertiary health facility. Low number of cases of other diagnostic findings can be due to lack of accessibility to an improved health center especially those in the rural areas and low population of people in the state. Early diagnosis should be done for effective management of these hematological disorders. Good family support and improved health care system with well trained personnel will help in management of the disease. VL - 6 IS - 2 ER -
Email: